Tissue Engineering

A practical seminar on 3D cell culture for tissue engineering from Fraunhofer ISC

Tissue Engineering

A practical seminar on 3D cell culture for tissue engineering from Fraunhofer ISC

The Fraunhofer Institute for Silicate Research ISC is to hold a seminar on Tissue Engineering in cooperation with the Chair of Tissue Engineering and Regenerative Medicine (TERM) at the University Hospital of Würzburg. The three-day event will provide a comprehensive overview of the basics of 3D cell culture for tissue engineering – in terms of both the biology and materials science. And it will also offer an insight into practical applications, ranging from personalized test systems to the development and approval of cell-based therapies.

Seminar details

Date: Nov 11–12, 2020
Place: online
Fee: €390  

Registration

Dr. Marco Metzger, head of the Translational Center, Würzburg

“Tissue engineering provides the tools for the medicine of the future: personalized therapies, from preclinical testing to cell-based tissue replacement.”

Seminar details

Regarding Covid-19 the Translational Center Regenerative Therapies decided to offer the next seminar in November 2020 online. Depending on the further developments the TLC plans to continue with in-person sessions in 2021.

Type of seminar

Fraunhofer seminar

 

Duration

2 days

 

Assessment

The seminar concludes with an assessment of learning outcomes.

 

Date  

November 11–12, 2020

 

Venue

online

 

Fee 

€390 (instead of €1,750) including seminar material and online assessment

 

© Fraunhofer ISC

Tissue engineers use interdisciplinary techniques to produce complex implants from the body’s own cells, stem cell sources and biocompatible substrate materials. Such implants minimize the risk of rejection and offer long-term physiological regeneration of impairments. Unlike conventional implants, this novel approach of advanced therapy medicinal products (ATMPs) also makes use of the body’s own self-healing capacities in order to exploit cellular mechanisms supporting a partial or complete restoration of impaired organ functions. Before the regulatory authorities can accept an ATMP for clinical trials, they require proof that such products comply with GMP (good manufacturing practice) requirements.

Before approval, developers must test new drugs and substances for their quality, efficacy and safety. In the absence of equivalent alternatives, the regulatory authorities prescribe animal experiments as mandatory in preclinical drug research. Due to species-specific differences, however, the results of animal experiments are not always transferable to humans. Hence there is a growing demand for alternative human test systems (tissue models) that reflect, for example, the complex properties of the human body and enable studies according to ADMET criteria (absorption, distribution, metabolism, and excretion and toxicity). In order to ensure proper 3D tissue maturation, developers must create in vitro culture conditions that correspond to the natural micro-environment of the cells in the body. Here, they use sophisticated bioreactor devices to ensure dynamic culture and physiological shear stress conditions. In addition, they may also make use of automation strategies (e.g. robot technologies) to achieve a high degree of standardization during tissue production and downstream testing.

The Fraunhofer seminar on Tissue engineering will provide a compact review of the basics of tissue engineering – in terms of both the biology and materials science. The two-day seminar will also offer an insight into practical applications at Fraunhofer ISC, ranging from personalized test systems to the development and approval of cell-based therapies.

The three-day seminar on “Tissue Engineering” will provide a comprehensive overview of the basics of tissue engineering – in terms of both the biology and materials science. It will also offer an insight into practical applications, ranging from personalized test systems to the development and approval of cell-based therapies.

Theoretical part

The two-day theoretical part comprises 12 modules of 45 minutes, including:

  • Cell biology of 3D tissue models
  • Biological and synthetic substrate materials
  • Process technology for the production of tissue models
  • Quality management for 3D cell culture systems
  • Clinical translation/GMP
 

Practical part

The practical component is modular. Participants can therefore select modules according to their prior knowledge and specific interests. The practical modules will take place in the laboratories of the Translational Center in Würzburg and the University Hospital of Würzburg. 

Module 1: Handling of stem cells and the growth of spheroid cultures

  • Primary intestinal stem cells and organoid modeling
  • Quality control
  • Carrying out swelling assays

Module 2: Applications in tissue engineering

  • Primary skin cells and creation of 3D transwell models
  • Noninvasive methods of quality control
  • Toxicity assay according to the OECD Guideline

 

Closure

Presentation of a robot platform for automated production and testing of in vitro models

 

Remarks

We have designed the seminar on the basis of many years of training experience in the major aspects in tissue engineering. Due to the dynamic progress of the field, we also adapt the course contents continuously. If necessary, we can supplement the seminar with customer-specific modules or design a completely new concept suitable to the specific needs of a whole group. If you have any further questions, please contact us.

The seminar addresses qualified scientists, technical staff and managers from industry, research institutions, and academia.

Sectors:

  • Manufacturers of chemical/pharmaceutical products
  • Cosmetics industry
  • Manufacturers of medicinal products
  • Health care (e.g. medical centers and hospitals)
  • Manufacturing industry (e.g. food processing)

The seminar “Tissue engineering” offers the following benefits:

  • Insights into current industry-related development projects in the field of regenerative medicine at the Fraunhofer ISC Translational Center Regenerative Therapies TLC-RT in Würzburg.
  • Compact teaching of applied expertise in 3D tissue engineering, including biomaterials and process technology.
  • Participants can select practical modules according to their prior knowledge and specific interests.
  • Teaching by experts with educational training and many years of experience in the field of tissue engineering in research and/or industry.